Lionel Messi was substituted with an arm injury that makes him a doubt for next weekend's Clasico but the Barcelona captain inspired a 4-2 home win against Sevilla to send his side top of LaLiga.
Philippe Coutinho scored from Messi's pass in the second minute to get Barca off to a flying start at Camp Nou on Saturday and the Argentina superstar soon doubled the lead.
But Messi had to be substituted having hurt his right arm in an awkward fall and he could miss Wednesday's Champions League game against Inter, as well as next Sunday's showdown with rivals Real Madrid.
Luis Suarez's second-half penalty and a late strike from Ivan Rakitic secured the points despite consolations from Pablo Sarabia and Luis Muriel, Ernesto Valverde's men moving into first place in the table, with Sevilla third after their four-game winning streak ended.
Despite being on a run of one win in five in all competitions, Barca led inside two minutes with Coutinho bending home a sensational first-time strike to complete a wonderful team move involving Messi and Suarez.
Guilherme Arana struck the post but Messi scored a typically brilliant second for his side in the 12th minute, running on to a superb Suarez pass and cutting inside off the right flank to find the bottom-left corner from 20 yards to record his 25th goal against Sevilla.
Messi, though, was then replaced by Ousmane Dembele after landing heavily on his right arm, Barca's treatment team initially patching him up but finding he could not continue.
Marc-Andre ter Stegen then produced a remarkable double stop before Suarez extended Barca's lead when he sent Tomas Vaclik the wrong way from the penalty spot after he was felled by the goalkeeper.
Sarabia's 79th-minute reply took a vital deflection off former Sevilla defender Clement Lenglet to ruin Ter Stegen's clean sheet, the Germany goalkeeper then making a second double save.
Rakitic added a late fourth with a controlled volley against his old club but Sevilla still had the final say, Muriel bending home a fine finish in added time.
Despite a welcome win, Barcelona will be concerned about Messi's injury ahead of next weekend's Clasico.
What does it mean: Messi major concern
Getting back to winning ways will be a huge relief for Valverde, but Messi's injury gives him another headache. Barca are arguably more reliant on their talisman than ever before and if he is out for any serious length of time, their title aspirations will be severely dented.
Ter Stegen heroics save Barca
A wonderful double save from Ter Stegen was a vital moment for Barca, who then quickly extended their lead from the penalty spot after Suarez was felled. The first save from Andre Silva's header was brilliant but blocking the rebound from Franco Vazquez was arguably even better. Incredibly, Ter Stegen made another amazing double save in the closing stages to keep out Muriel and Sarabia.
Ben Yedder toothless for visitors
Behind Messi and level with team-mate Sarabia, Wissam Ben Yedder was among LaLiga's top scorers this term with nine in all competitions, but the striker had little involvement. Sevilla - now winless in 16 games at Camp Nou - were on the back foot from the off, however, blunting his impact.
Key Opta Facts
- Messi and Cristiano Ronaldo have scored 25 goals vs Sevilla in LaLiga each one, a shared player record against an opponent in the competition.
- Messi has been involved in at least a goal in 18 out of last 19 meetings versus Sevilla in all competitions (19 goals and 12 assists).
- Coutinho scored the second fastest goal in La Liga this season (01:58), only after the goal scored by Ezequiel Garay for Valencia against Barca.
- Sevilla had completed 19 shots (including blocks) against Barcelona, the most for a team against Ernesto Valverde's side in all competitions this season.
European action for both sides this week with Barca hosting Inter in the Champions League on Wednesday and Sevilla welcoming Akhisarspor in the Europa League a day later. On Sunday it's Huesca at home for Sevilla, while Barca will hope Messi is fit to face Madrid in the Clasico.
|Niasse joins Cardiff on loan from Everton|
|Hendrick credited with Fulham strike|
|Western Sydney Wanderers 1 Adelaide United 2: Goodwin compounds Wanderers woes|
|Chahal and Dhoni carry India to ODI triumph|
|Levante report Barcelona for alleged use of ineligible player in Copa del Rey|
|Solskjaer regrets Sanchez´s Reading setback|
|Tomic brands Hewitt a ´liar´ as feud continues|
|Ruthless Nadal thrashes teenager De Minaur|
|Wozniacki enjoyed status as defending champion in Melbourne|
|Solskjaer backs Mourinho to return to football´s big time|
|Murray to miss Open 13 Marseille|
|Solskjaer´s United turnaround no easy task, says Hughton|
|The big Friday Premier League quiz|
|How James Harden´s 2018-19 numbers compare to his MVP campaign|
|It´s insane! - Tsitsipas excited to face ´legend´ Federer|
|Sharapova ends Wozniacki title defence|
|American teen Anisimova sends records tumbling at Aus Open|
|Lakers survive Ball´s gaffe to beat Thunder in OT|
|Federer expects ´athletic´ and ´attacking´ Tsitsipas clash|
|Alcacer is fit and available – Favre|
|Fantastic Federer breezes past Fritz|
|Pogba happy with Man United approach under Solskjaer|
|Mickelson leads Desert Classic, ties career-low with 12-under 60|
|Warriors´ Durant on Curry: He´s a once-in-a-generation, once-in-a-lifetime talent|
|Patriots owner says Brady is greatest player, not just quarterback, of all time|
|Inglis to retire from representative duty this year, NRL in 2020|
|Is Beal better without Wall? Wizards star says it´s ´absolutely nonsense´|
|Rockets C Capela undergoes thumb surgery, expected back after All-Star break|
|This Week in U.S. Sports: Irving apologises, Machado´s agent isn´t happy|
|Knicks in woeful shape, but 2019 could still be bright in New York|
|Valverde not worried about Levante´s Copa appeal|
|Nowell an option for England at flanker, reveals Jones|
|Pellegrini: Arnautovic available for the right price|
|Knicks throw away 19-point lead and lose on last-second goaltending call|
|Tebow invited back to Mets´ major league spring training|
|Canelo and Jacobs agree unification fight|
|Barcelona 3 Levante 0 (4-2 agg): Dembele at the double as Barca advance|
|Levante to lodge complaint over Barcelona Copa selection|
|Kanter´s London absence ´very unfortunate´, says NBA commissioner|
|NBA could swap London for Paris in 2020|
|Spurs coach Popovich uncertain if he will return next season|
|Pistons´ Griffin fined for verbal abuse of official|
|Everton do not have financial conditions to enter transfer market - Silva|
|Andy Cole joins Sol Campbell´s coaching staff at Macclesfield|
|Atletico confirm Saul has thigh injury|
|Wood replaces injured Stone in England squad|
|Lebanon 4 North Korea 1: Disciplinary record cruelly denies Radulovic´s men|
|Saudi Arabia 0 Qatar 2: In-form Ali bags brace as Qatar top group|
|Robertson signs new Liverpool deal|
|Vunipola backs Farrell to thrive in solo leadership role|
|People don´t know what´s going on behind the scenes - Mourinho defends United stint|
|Indefatigable Muguruza knocks out Konta at 3:12am|
|Serena coasts, difficulties for Halep and Muguruza´s marathon|
|Lowry retains Abu Dhabi lead|
|Djokovic battles past Tsonga, young guns flourish|
|Louisville airport to be renamed in Muhammad Ali´s honour|
|Emery not thinking about Ozil speculation|
|Sri Lanka hopeful over Kusal Mendis finger injury|
|Oman 3 Turkmenistan 1: Last-gasp Al-Musallami guarantees progression|
|Emery wants Cech to end career ´in a good moment´|
|Japan 2 Uzbekistan 1: Shiotani stunner seals comeback and top spot|
|Calhanoglu deal ´financially impossible´ for Leipzig|
|Not seen at Aus Open since Nadal, Djokovic and Murray in 2009 – ´Next Gen´ make move|
|Martial: Solskjaer lets me express myself|
|Djokovic sees off Tsonga to reach third round|
|Returning Cousins calls Warriors ´the most hated team in sports´|
|Halep injury ´nothing dangerous´|
|Warner picks up elbow injury in Bangladesh|
|Mkhitaryan returning to Arsenal training next week|
|Leeds United pounce for Real Madrid goalkeeper Casilla|