Serena Williams and her comeback was cut short by sister Venus at Indian Wells, while world number two Caroline Wozniacki survived.
Playing her first competitive tournament since the 2017 Australian Open, 23-time grand slam champion Serena fell to Venus in straight sets on Monday.
Joining Venus in the fourth round was Australian Open champion Wozniacki, who was less than convincing in the desert.
Meanwhile, defending champion Elena Vesnina was bundled out by Angelique Kerber earlier in the day.
VENUS OUTSHINES SERENA
While all eyes were on Serena, Venus stole the show in her 6-3 6-4 victory.
Venus, the eighth seed, was a class above in the 29th meeting between the Williams sisters – Serena boasting a 17-11 head-to-head record before the blockbuster clash.
The seven-time major winner defeated Serena for the first time since 2014, while claiming her first straight-sets win against her youngster sister since 2008, despite a late stumble.
Venus was leading 5-2 when she wasted a match point and the 37-year-old needed to fend off a break point in the 10th game before closing it out.
WOZNIACKI MUDDLES THROUGH
It was far from convincing as Wozniacki prevailed 6-4 2-6 6-3 against Aliaksandra Sasnovich.
Wozniacki overturned a 4-1 deficit in the opening set as she reeled off five successive games to take the lead.
The Danish star could not stop Sasnovich in the second set, however, as a decider loomed.
But Wozniacki managed to compose herself, regrouping after dropping the opening game before progressing.
Wozniacki, who will face 20th seed Daria Kasatkina for a spot in the quarter-finals, said: "I was struggling finding my rhythm. I didn't really feel comfortable out there today. Didn't really get my game going the way I wanted to."
KERBER DETHRONES VESNINA
Vesnina's title defence was ended by two-time grand slam winner Kerber, who triumphed 7-5 6-2.
After losing the first four games of the match, Vesnina responded by winning five on the bounce for a chance to serve for the set.
But Vesnina never earned a set point as Kerber overcome a marathon first set – saving break points and reeling off the final three games.
The second set was more straightforward for Kerber, who will now play Caroline Garcia in the last 16 after the Frenchwoman eliminated Daria Gavrilova 7-5 6-4.
"I know what to expect. I played against her at the end of last year," Kerber said. "It's another quite big match for me, and I will go out there, try to play like I played the last weeks and try to enjoy the next match."
Reigning US Open champion Sloane Stephens and fourth seed Elina Svitolina were among those to bow out.
|Raiola rages over Italy´s Balotelli snub|
|Injured Saunders postpones Murray fight|
|PGA tightens security at Dell Match Play in wake of Austin bombings|
|Raiola hopes Reina to Milan hastens Donnarumma exit|
|F1 Raceweek: Hamilton prepares to begin title defence in Melbourne|
|Former Sevilla coach Berizzo eyeing return after beating cancer|
|Cutrone did not expect whirlwind Milan season and Italy call-up|
|Saints punish North for missing training|
|´Happy´ Kepa mulled over Real Madrid move|
|GGG wants Saunders next if Alvarez bout is called off|
|Former All Black Mika passes away|
|Lucas Vazquez keen on Real Madrid stay|
|South Africa delighted to call on ´world´s best´ Rabada|
|Tiger Woods continues climb in FedEx Cup, world rankings|
|Juventus clear Chiellini of serious injury|
|Newcastle charged as youth team allegedly breach advertising regulations|
|Kearney joins Best in extending Ireland contract|
|I did not betray Roma – Pjanic could not pass up Juventus opportunity|
|Cardiff Blues appoint Mulvihill as Wilson replacement|
|Title-chasing Sarri closes on Napoli renewal as he hopes to repay fans|
|Cook: I wasn´t close to quitting during Ashes|
|Messi and Ronaldo reveal World Cup kits|
|Nara praises Inter project as Icardi talks continue|
|Best to lead Ireland in World Cup after signing extension|
|Marseille´s Rami wants to ´tickle´ PSG|
|Fury targeting Louis´ record for title defences|
|Salah can push on to Messi´s level - Robertson|
|Rabada free to play in rest of South Africa-Australia series|
|F1 2018: Halo splits opinion ahead of Australia debut|
|Iniesta better than last year – Lopetegui|
|Federer yet to decide on clay-court season|
|Okon quits as Mariners head coach|
|LeBron triple-double powers Cavs past Bucks as Love returns|
|Lopetegui: Morata must earn World Cup spot|
|Ronaldo has asked about China – Scolari|
|Ebron signs two-year deal with Colts|
|Spieth, Reed to do battle in Match Play|
|Rangers´ Perez slaughtered, ate bull that caused broken elbow|
|Bills improve offensive line with Bodine, Newhouse|
|Braves phenom Acuna to start season in minors|
|Chargers add Pouncey on two-year deal|
|Ronaldo: I always show I´m the best|
|Joshua would love another Whyte tear-up, says Hearn|
|Manchester United not in Jorginho talks, says Napoli star´s agent|
|Hazard will not be false nine for Belgium, says Martinez|
|Bancroft confident on Starc and Marsh fitness|
|Mayweather to apply for MMA licence|
|Martial agent will not guarantee Manchester United stay|
|Del Potro and Djokovic on early collision course at Miami Open|
|Siemian swaps Broncos for Vikings|
|Broad chomping at the bit to bowl at Black Caps´ Taylor|
|Ronaldo slams ´fake news´ amid latest tax case claims|
|Van Dijk and Gundogan expect tough City-Liverpool tie|
|VAR to be introduced in Eredivisie|
|Di Biagio sees bright Italy future with Cutrone and Chiesa|
|Koeman won´t rule out Van Persie Netherlands return|
|I ate badly for years – how Messi solved his vomiting problem|
|England and Bath´s Watson out for the season|
|McLaren issues ´have been addressed´ ahead of F1 season opener|
|Tuchel feels he would still be at Dortmund without bomb attack|
|Pogba shows off new haircut as Ben Yedder trolls Man United star|
|Pogba cannot be happy but must focus on France, says Deschamps|
|Samuels slogs Windies closer to World Cup qualification|
|Having Rabada in third Test massive - Elgar|
|Cavs coach Lue steps away from job due to health reasons|
|Debuchy disappointed to be left out of latest France squad|
|Barton rejects England´s World Cup chances|
|Hamilton can become greatest F1 driver in history - Kovalainen|
|Sevilla coach Montella interested in Italy job|
|Football brain lacking, poor attitude and fourth choice – The Mourinho-Shaw saga at Manchester Unite|