The New England Patriots and Atlanta Falcons were left searching for answers after surprise losses to the Tennessee Titans and Cleveland Browns respectively.
In Nashville, Marcus Mariota passed for 228 yards and two touchdowns and running back Derrick Henry rushed for 58 yards and two scores as the Titans thumped the Patriots 34-10.
The Titans' defense sacked Tom Brady three times and held the high-scoring Pats offense to 284 total yards. The Patriots fell to 7-3, while the Titans are 5-4.
In Cleveland, Browns rookie running back Nick Chubb rushed for 176 yards, added 33 more through the air and scored twice as the Browns upset Atlanta 28-16. He also provided the highlight of the day with a 92-yard TD run, the longest in franchise history.
Elsewhere, the two Los Angeles teams faced challenges but prevailed. In Oakland, Chargers quarterback Philip Rivers did not have a completion until the second quarter, but once he and running back Melvin Gordon got rolling, LA won 20-6 to improve to 7-2.
The Rams, who had never lost back-to-back games in the Sean McVay era, were close to doing so on Sunday when they hosted the Seahawks. Seattle quarterback Russell Wilson tried to engineer one of his famous fourth-quarter comebacks but fell short, going four-and-out on the final drive. Los Angeles (9-1) claimed a 36-31 victory to solidify their spot atop the NFC West.
Patriots receiver Julian Edelman injured his ankle in the team's loss to the Titans. He exited the game early and never returned. Other New England players that were injured in the contest were offensive tackle Trent Brown (back) and tight end Dwayne Allen (knee).
New Orleans left tackle Terron Armstead left the Saints' matchup against the Bengals after sustaining a shoulder injury during the first half. He was then ruled out of the game.
Raiders wide receiver Martavis Bryant was ruled out with a knee injury. A later report stated Bryant suffered a possible PCL tear, and will have an MRI to determine the severity of the injury.
A number of Packers were injured as Green Bay hosted the Dolphins. Safety Kentrell Brice left the game with an ankle injury, linebacker Nick Perry suffered a new injury, and guard Lucas Patrick was evaluated for a concussion.
Bengals cornerback Dre Kirkpatrick was unable to finish the game against the Saints after suffering a concussion.
Miami cornerback Bobby McCain was ruled out of the game with a head injury. Team-mate and receiver Jakeem Grant was carted off to the locker room with a leg injury. Fellow receiver DeVante Parker suffered a shoulder injury.
Rams wideout Cooper Kupp suffered another knee injury against the Seahawks and did not return.
By the numbers
Chiefs QB Patrick Mahomes threw for his 31st touchdown against the Cardinals, setting the franchise record for most touchdown passes in a single season, breaking a mark set by Len Dawson in 1964.
Single-season touchdown record broken...in 10 games. pic.twitter.com/V9HOhEcnoR— Kansas City Chiefs (@Chiefs) November 11, 2018
Falcons receiver Julio Jones became the fastest player in NFL history to reach 10,000 receiving yards. He reached the milestone in his 104th game.
Drew Brees passed Brett Favre for second-most passing touchdowns in NFL history, breaking the Hall of Famer's mark of 508 with three first-half touchdown passes against the Bengals.
The Redskins suffered a big loss to the Falcons last week. This time around, Washington were not going to be on the losing end. Linebacker Ryan Anderson attributed the win to a sense of urgency: "We got our [expletives] kicked last week, so everybody had a sense of urgency. That's what playing good defense is about. We let them make some plays, they hit us on some stuff. So, we had to just come out and respond. Bend, but don't break."
The Bills thrashed the Jets 41-10, leaving New York receiver Jermaine Kearse and company frustrated: "Everybody's frustrated. I understand the fans are frustrated. We're frustrated. It's understandable. We're going to stick together. We're going to stick with Todd [Bowles, head coach]. We're going to have his back."
Week 10 NFL scores
Pittsburgh Steelers 52, Carolina Panthers 21
Washington Redskins 16, Tampa Bay Buccaneers 3
Kansas City Chiefs 26, Arizona Cardinals 14
Cleveland Browns 28, Atlanta Falcons 16
Buffalo Bills 41, New York Jets 10
Indianapolis Colts 29, Jacksonville Jaguars 26
Chicago Bears 34, Detroit Lions 22
New Orleans Saints 51, Cincinnati Bengals 14
Tennessee Titans 34, New England Patriots 10
Los Angeles Chargers 20, Oakland Raiders 6
Los Angeles Rams 36, Seattle Seahawks 31
Green Bay Packers 31, Miami Dolphins 12
Dallas Cowboys 27, Philadelphia Eagles 20
|Westbrook on Murray scuffle: He was in my way|
|Liverpool v Manchester United: Van Dijk the rock on which Klopp can build a title triumph|
|Marcelo ´never´ considered Madrid exit amid Juventus links|
|Liverpool v Manchester United: Resurgent Rashford now a leader for Mourinho|
|Injury-plagued Nuggets beat Thunder to hold Western Conference lead|
|Southee takes five as Sri Lanka recover in Wellington|
|Kings troll Curry by playing clips of moon landing|
|Guardiola: Premier League title race similar to Barca-Madrid battles|
|Ovechkin joins rare NHL club with second straight hat-trick|
|Liverpool can´t be judged just on trophies – Klopp responds to Mourinho|
|Athletics´ Chapman undergoes procedure on left shoulder|
|Marcelo: Real Madrid miss Ronaldo|
|Ronaldo right about Juventus team spirit – Allegri|
|Klopp: I´m not the pope of football tactics|
|Stade beat Ospreys on emotional Chauvin tribute night|
|Ligue 1 survival bid a marathon not a sprint for Monaco, as club appoints distance runner|
|Vertonghen eyeing Spurs future beyond 2020|
|De Bruyne injuries could be a blessing for City, says Guardiola|
|Emery prepared to face Arsenal´s centre-back crisis|
|Ulster complete Scarlets double, Exeter gain Gloucester revenge|
|Sheffield United 1 West Brom 2: Baggies comeback boosts automatic promotion push|
|Del Potro back on court following knee injury|
|Canelo v Fielding: Rocky ready to write his own fairytale in New York|
|Boca part company with Schelotto after Copa Libertadores loss to River|
|Canelo v Fielding: Tale of the tape|
|Juventus defender Cancelo has knee surgery|
|Canelo v Fielding: Alvarez and Rocky make weight in New York|
|Spalletti does not fear another mid-season crisis at Inter|
|Salah headlines CAF Player of the Year shortlist as Koulibaly misses out|
|Beckham Jr. out of Titans clash|
|Lipsky hits the front at Leopard Creek|
|Pederson coy over Wentz back injury|
|Liverpool ´not really likely´ to be active in January window, reveals Klopp|
|Always on the move and unpredictable - Pavard reveals surprising choice over toughest opponent|
|We need to get back to respect - Lampard alarmed by hate in football|
|Giles returns to England to replace Strauss as director|
|Hansen has no issue with Milner-Skudder Toulon switch|
|Juventus to rest Ronaldo after Torino showdown|
|Titmus strikes gold again as world records tumble in Hangzhou|
|Malinga to captain Sri Lanka in New Zealand|
|Rivaldo would like ´excellent´ Isco at Barcelona|
|United a long way from Mourinho´s vision|
|´Klopp denies an answer!´ - Liverpool boss dismisses questions about ´world-class´ Pogba|
|Returning Nowitzki ´so tired´ after making NBA history|
|Aguero and De Bruyne in contention for Manchester City v Everton|
|Simeone has no plans to cash in on Costa|
|Canelo v Fielding: Alvarez´s greatest nights|
|Fabregas: Chelsea being unfairly scapegoated over racism allegations|
|Crisis? What crisis? Klopp focuses on defensive solutions for United clash|
|Hope cannot inspire Windies as Bangladesh cruise to series win|
|Benitez picks up Premier League Manager of the Month award|
|Chavez, Marquez and Canelo - Mexico´s greatest multi-weight world champions|
|Bale set to miss Real Madrid v Rayo Vallecano|
|Robben out until January as Bayern look to avoid serious injury|
|Milan avoid UEFA ban in FFP punishments.|
|Mourinho compares Liverpool to ´an amazing house´ but insists trophies matter|
|Brisbane Roar 2 Melbourne Victory 4: Muscat´s men hit A-League summit|
|Bumrah confident second Test is ´in the balance´ after India recovery|
|Isco gesture was for a corner or foul, claims Solari|
|Harris leads Australia into ascendancy on day one|
|ATP announces candidates to host future Finals|
|Ronaldo: Juventus fans refuse to lose to Torino|
|Hero Rivers feared he had cost Chargers in KC|
|Williams would welcome Llorente back to Athletic Bilbao|
|Liverpool v Manchester United: Minding the gap|
|Milan elimination unjust, fumes Leonardo|
|Paul hails ´sick´ Harden after record-breaking display|
|Liverpool v Manchester United: Salah, Mane and Firmino v Rashford, Martial and Lukaku in Opta number|
|Canelo open to GGG trilogy as he chases place in Mexican history|
|The big Friday Premier League quiz|